breviscapine/scutellarin/erigeron breviscapus/breviscapinun Cas.No.:116122-36-2
Breviscapine is a mixture of flavonoid glycosides extracted from the Chinese herbs. Previous studies have shown that breviscapine possesses comprehensive pharmacological functions. However, very little is known about whether breviscapine have protective role on cardiac hypertrophy. The aim of the present study was to determine whether breviscapine attenuates cardiac hypertrophy induced by angiotensin II (Ang II) in cultured neonatal rat cardiac myocytes in vitro and pressure-overload-induced cardiac hypertrophy in mice in vivo. Our data demonstrated that breviscapine (2.5-15 microM) dose-dependently blocked cardiac hypertrophy induced by Ang II (1 microM) in vitro. The results further revealed that breviscapine (50 mg/kg/day) prevented cardiac hypertrophy induced by aortic banding as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha-dependent ERK1/2 and PI3K/AKT signaling. Further studies showed that breviscapine inhibited inflammation by blocking NF-kappaB signaling, and attenuated fibrosis and collagen synthesis through abrogating Smad2/3 signaling. Therefore, these findings indicate that breviscapine, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of PKC-alpha-dependent signaling.
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Product name:Erigeron breviscapus Extract
Extract source:Erigeron breviscapus(Vant. )Hand.-Mazz
Active ingredient:Breviscapine(breviscapinun)( Erigeron Breviscapus)
Used Part:whole herb
CAS NO. : 116122-36-2
Molecular formula :C21H18O12
Molecular weight:462.4
Appearance:light yellow Powder
Usage: Pharmaceuticals, healthcares,and cosmetics
Specification Available:95% 98%HPLC
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Application
Expand blood vesse in cerebra, Antiplatelet assemble, used to cure lack-blood evocable Cerebrovascular disease, like Cerebral thrombus, Cerebral embolism, Encephalorrhagia
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Main Function:
1, to improve cerebral blood circulation, increase cerebral blood flow, reducing vascular resistance, increase the permeability of the blood-brain barrier, conducive to the prevention and treatment of cerebral thrombosis formation.
2, the expansion of the coronary artery and peripheral vascular, reducing myocardial oxygen consumption, to increase nutrition myocardial blood flow, improve myocardial microcirculation.
3, lower cholesterol, reduce high blood viscosity, platelet aggregation.
4, increasing the phagocytic function of the liver reticuloendothelial cells and macrophages, increased blood CAMP content, improve the immune system.
5, inhibition of intravascular coagulation, fibrinolysis promoting, reducing fibrinogen, and anti-tied thrombolysis.
